I’ve played a few cool courses in the Orlando area. I usually get 2-3 rounds in while at the PGA Merchandise Show in January of every year. One time though, I did the 2.5 hour drive to PGA Tour headquarters and played the TPC Sawgrass. That course is I recommend everyone play at least once in your lifetime to see what the course is like.
If you are looking for courses in Orlando area though, perhaps while the wife and/or kids are spending time at Disney World, check out Orlando Golf for packages and information on Orlando golf courses.